Preimplantation development in ungulates: a ‘ménage à quatre’ scenario

Un Ménage à Quatre The Molecular Biology of Chromosome Segregation in Meiosis

Sexually reproducing organisms rely on the precise reduction of chromosome number during a specialized cell division called meiosis. Whereas mitosis produces diploid daughter cells from diploid cells, meiosis generates haploid gametes from diploid precursors. The molecular mechanisms controlling chromosome transmission during both divisions have started to be delineated. This review focuses on ...

Synaptic Ménage à Trois

Regulation of neurotransmitter receptor localization is critical for synaptic function and plasticity. In this issue of Neuron, Matsuda and colleagues (Matsuda et al., 2016) uncover a transsynaptic complex consisting of neurexin-3, C1q-like proteins, and kainate receptors that drives glutamate receptor clustering at hippocampal synapses.

Ménage à trois

Ménage à trois

Glioblastoma is an aggressive primary brain cancer. Given our interest in novel immunotherapies, we have recently shown that inhibiting CTLA-4, PD-L1 and IDO results in a dramatic survival advantage in mice with brain tumors. Our preclinical study supports the rapid translation of this approach into phase I clinical trial.

Plant meristems: A ménage à trois to end it all

Regulated termination of stem cell maintenance is required to complete reproductive development in plants. Two recent studies have revealed a new relationship for some old suspects; the WUSCHEL gene, which promotes indeterminancy, is involved as well as the floral regulators LEAFY and AGAMOUS.